Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.45 |
| ▸ | CCR1 | P32246 | 4/20 | 0.43 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | PLD2 | O14939 | 1/20 | 0.36 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.34 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8010542 | 0.87 | TRPV4 (0.44) | TRPV4CCR1KMT2A | |
| SCHEMBL4053067 | 0.85 | TRPV4 (0.46) | TRPV4CCR1CTSKCASP1CASP3 | |
| SCHEMBL8012366 | 0.82 | TRPV4 (0.54) | TRPV4CCR1CTSKUTS2RPSMB5 | |
| SCHEMBL8006938 | 0.82 | TRPV4 (0.53) | TRPV4CCR1CTSKUTS2RPIN1 | |
| SCHEMBL8012369 | 0.81 | TRPV4 (0.38) | TRPV4CASP3PIN1 | |
| SCHEMBL8006828 | 0.80 | TRPV4 (0.51) | TRPV4CCR1CTSKUTS2R | |
| SCHEMBL8012364 | 0.79 | TRPV4 (0.49) | TRPV4CCR1CTSKUTS2R | |
| SCHEMBL8006169 | 0.78 | TRPV4 (0.50) | TRPV4CCR1CTSKUTS2RPIN1 | |
| SCHEMBL8008220 | 0.78 | TRPV4 (0.66) | TRPV4CCR1CTSKUTS2RPIN1 | |
| SCHEMBL8008215 | 0.77 | TRPV4 (0.65) | TRPV4CCR1CTSKUTS2RPIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009111680-A1 | TRPV4 ANTAGONISTS | SMITHLINE BEECHAM CORPORATION (US) | 2009-09-11 | — | — | WO | disclosed |