Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7572963 | 0.78 | HTR2A (0.48) | HTR2AALDH1A1CYP2A6MAOALMNA | |
| SCHEMBL6048471 | 0.78 | ALDH1A1 (0.43) | HTR2AALDH1A1DPP4MAOBTSHR | |
| SCHEMBL3511627 | 0.76 | DPP4 (0.48) | HTR2ADPP4F2LMNA | |
| SCHEMBL20915029 | 0.76 | DPP4 (0.48) | HTR2ADPP4F2LMNA | |
| SCHEMBL28772606 | 0.76 | DPP4 (0.48) | HTR2ADPP4F2LMNA | |
| SCHEMBL2594007 | 0.74 | ALDH1A1 (0.46) | HTR2AALDH1A1DPP4MAOBTSHR | |
| SCHEMBL3647646 | 0.72 | HTR2A (0.35) | HTR2AALDH1A1DPP4MAOBTSHR | |
| SCHEMBL9960125 | 0.72 | MAOB (0.50) | HTR2AALDH1A1MAOBCYP19A1MAOA | |
| SCHEMBL315078 | 0.71 | HTR2A (0.41) | HTR2AALDH1A1MAOBTSHRCYP2A6 | |
| SCHEMBL184701 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MAOBTSHRCYP2A6CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763016-B1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | AXYS PHARM INC (US) | 2000-01-26 | — | — | EP | claimed |
| EP-0763016-B1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | AXYS PHARM INC (US) | 2000-01-26 | — | — | EP | disclosed |
| EP-0763016-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995032945-A1 | COMPOSITIONS AND METHODS FOR TREATING MAST-CELL MEDIATED CONDITIONS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1995-12-07 | — | — | WO | disclosed |