Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8005263 | 0.88 | SMN1; SMN2 (0.46) | HTTSMN1; SMN2ALDH1A1HCRTR2MEN1 | |
| Hydrochloric Acid SCHEMBL8004278 | 0.88 | SMN1; SMN2 (0.47) | HTTSMN1; SMN2ALDH1A1MAPK14MEN1 | |
| SCHEMBL8005080 | 0.79 | KMT2A (0.51) | SMN1; SMN2ALDH1A1MEN1KMT2APDGFRB | |
| Hydrochloric Acid SCHEMBL7995813 | 0.78 | KMT2A (0.50) | SMN1; SMN2ALDH1A1MEN1KMT2APDGFRB | |
| Hydrochloric Acid SCHEMBL8007541 | 0.78 | CCNT1 (0.45) | SMN1; SMN2ALDH1A1MAPK14KMT2APDGFRB | |
| SCHEMBL8444019 | 0.78 | CA12 (0.54) | HTTSMN1; SMN2ALDH1A1USP2SETD7 | |
| SCHEMBL8440609 | 0.77 | HPGD (0.46) | HTTSMN1; SMN2ALDH1A1USP2MEN1 | |
| Hydrochloric Acid SCHEMBL8004286 | 0.77 | CYP2D6 (0.47) | SMN1; SMN2ALDH1A1SETD7MEN1KMT2A | |
| SCHEMBL8440765 | 0.76 | MAPK1 (0.45) | SMN1; SMN2ALDH1A1USP2SETD7MEN1 | |
| Hydrochloric Acid SCHEMBL8663603 | 0.76 | CYP2D6 (0.47) | SMN1; SMN2ALDH1A1KMT2APDGFRBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6017917-A | Guanidine derivatives | FUJISAWA PHARAMCEUTICAL CO., LTD. (JP) | 2000-01-25 | — | — | US | disclosed |
| EP-0876338-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997025310-A1 | GUANIDINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-07-17 | — | — | WO | disclosed |