Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 15/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16258580 | 0.84 | NOTUM (0.63) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL11965639 | 0.81 | NOTUM (0.59) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL4791133 | 0.79 | NOTUM (0.58) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL30578696 | 0.79 | NOTUM (0.65) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL16980527 | 0.79 | NOTUM (0.57) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL17148987 | 0.76 | NOTUM (0.60) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL1459174 | 0.76 | TSHR (0.62) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL28154291 | 0.76 | NOTUM (0.58) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL30221689 | 0.76 | TSHR (0.62) | NOTUMALDH1A1HPGDMAPK1KDM4E | |
| SCHEMBL23451501 | 0.75 | NOTUM (1.00) | NOTUMALDH1A1HPGDMAPK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299824-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME (US) | 2013-06-19 | — | — | EP | disclosed |
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK SHARP & DOHME CORP. | 2011-06-16 | — | — | US | disclosed |
| WO-2009151991-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | MERCK & CO., INC. (US) | 2009-12-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144056-A1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH | FAAH, FAAH2, HRH2 | NOTUM 562/4885ALDH1A1 1185/4885HPGD 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.