Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | PI4KA | P42356 | 2/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.44 |
| ▸ | SLC28A1 | O00337 | 2/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.44 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.44 |
| ▸ | GAPDH | P04406 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | STAT6 | P42226 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16094305 | 0.87 | ADORA3 (0.41) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL29140449 | 0.86 | PI4KA (0.46) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL31541268 | 0.86 | PI4KA (0.46) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL3446750 | 0.85 | PI4KA (0.48) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL3447136 | 0.83 | ADORA3 (0.50) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL2297051 | 0.82 | ADORA2A (0.47) | ADORA3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL25349321 | 0.81 | ADORA3 (0.49) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL28351254 | 0.81 | ADORA3 (0.51) | ADORA3ADORA2AEGFRERBB2PI4KA | |
| SCHEMBL8704526 | 0.81 | AHCY (0.47) | ADORA3ADORA2API4KAPI4K2BPI4K2A | |
| SCHEMBL8612419 | 0.80 | ADORA3 (0.47) | ADORA3ADORA2AEGFRERBB2PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6022691-A | DETECTING A CHEMICAL OR DRUG IN A SAMPLE; CONTACTING THE SAMPLE WITH A NUCLEOTIDE SEQUENCE WHICH HYBRIDIZES TO A SPECIFIC TARGET MOLECULE, DETECTING BINDING OF NUCLEOTIDE SEQUENCES, BINDING IS INDICATION OF DRUG OR CHEMICAL PRESENT | ISIS PHARMACEUTICALS, INC. (US) | 2000-02-08 | — | — | US | disclosed |
| US-5747253-A | Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding | ISIS PHARMACEUTICALS, INC. (US) | 1998-05-05 | — | — | US | disclosed |
| US-5698391-A | DETERMINATION OF TARGET PROPERTY; BIOSYNTHESIS CYCLES | ISIS PHARMACEUTICALS, INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5686242-A | Determination of oligonucleotides for therapeutics, diagnostics and research reagents | ISIS PHARMACEUTICALS, INC. (US) | 1997-11-11 | — | — | US | disclosed |
| US-5672472-A | REPEATED ENZYME-FREE SYNTHESIS OF INCREASINGLY SIMPLIFIED SETS OF OLIGONUCLEOTIDES WHILE DETERMINING WHICH SEQUENCE HAS HIGHEST TARGET ACTIVITY | ISIS PHARMACEUTICALS, INC. (US) | 1997-09-30 | — | — | US | disclosed |
| EP-0673435-A4 | — | — | 1995-10-25 | — | — | EP | disclosed |
| EP-0673435-A1 | SYNTHETIC UNRANDOMIZATION OF OLIGOMER FRAGMENTS | ISIS PHARMACEUTICALS, INC. (US) | 1995-09-27 | — | — | EP | disclosed |
| WO-1994021825-A1 | COMBINATORIAL OLIGOMER IMMUNOABSORBANT SCREENING ASSAY FOR TRANSCRIPTION FACTORS AND OTHER BIOMOLECULE BINDING | ISIS PHARMACEUTICALS, INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| WO-1993005182-A1 | DETERMINATION OF OLIGONUCLEOTIDES FOR THERAPEUTICS, DIAGNOSTICS AND RESEARCH REAGENTS | ISIS PHARMACEUTICALS, INC. (US) | 1993-03-18 | — | — | WO | disclosed |
| WO-1993004204-A1 | SYNTHETIC UNRANDOMIZATION OF OLIGOMER FRAGMENTS | ISIS PHARMACEUTICALS, INC. (US) | 1993-03-04 | — | — | WO | disclosed |