Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152764 | 1.00 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28180684 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL28845740 | 0.87 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KMT2AMEN1NPC1 | |
| SCHEMBL27346857 | 0.84 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1MAPTNPC1ATM | |
| SCHEMBL27446293 | 0.82 | TSHR (0.50) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL7457347 | 0.82 | TSHR (0.50) | SMN1; SMN2MAPTKMT2AMEN1LMNA | |
| SCHEMBL6153115 | 0.81 | HIF1A (0.43) | SMN1; SMN2MAPTNPC1LMNARAB9A | |
| SCHEMBL8435839 | 0.81 | TSHR (0.47) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL8435835 | 0.81 | TSHR (0.47) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL6025082 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675133-B1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO CO (JP) | 2000-01-12 | — | — | EP | disclosed |
| US-5614470-A | AGRICULTURAL ANTHELMINTIC, ACARICIDE, INSECTICIDE | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| EP-0675133-A1 | 13-Substituted milbemycin derivatives, their preparation and use | SANKYO COMPANY LIMITED (JP) | 1995-10-04 | — | — | EP | disclosed |