Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15216113 | 0.86 | KDM4E (0.42) | ALDH1A1SMN1; SMN2KDM4EPOLBMAPT | |
| SCHEMBL15216084 | 0.80 | ACHE (0.40) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL7993475 | 0.80 | PDE3B (0.37) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL15216087 | 0.79 | SLC2A1 (0.42) | ALDH1A1SMN1; SMN2KDM4ENPC1GAA | |
| SCHEMBL8011476 | 0.79 | MEN1 (0.36) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL8006881 | 0.77 | MEN1 (0.35) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL8008296 | 0.77 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL577492 | 0.76 | SMN1; SMN2 (0.36) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL8008865 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB | |
| SCHEMBL8008888 | 0.75 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KDM4ENPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250174-B1 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARMACEUTICALS INC (US) | 2013-08-28 | — | — | EP | disclosed |
| WO-2009099596-A2 | MACROCYCLIC SERINE PROTEASE INHIBITORS | IDENIX PHARAMACEUTICALS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |