Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 18/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 17/20 | 0.57 |
| ▸ | GAA | P10253 | 6/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8007959 | 1.00 | KDM4E (0.57) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL12496383 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL12496385 | 0.79 | KDM4E (0.46) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| Dimethylamine SCHEMBL8007963 | 0.78 | ALDH1A1 (0.32) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL361527 | 0.76 | MAPT (0.38) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL2969079 | 0.72 | KDM4E (0.49) | KDM4EALDH1A1GAAHTTSMN1; SMN2 | |
| SCHEMBL8007955 | 0.72 | NPC1 (0.32) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL2964668 | 0.71 | PTGS1 (0.36) | KDM4EALDH1A1HTTSMN1; SMN2MEN1 | |
| SCHEMBL2964035 | 0.71 | ALDH1A1 (0.43) | KDM4EALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL10279750 | 0.68 | PDE4D (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000119274-A | TRIAZOLOPYRIMIDINE DERIVATIVE | NIPPON BAYER AGROCHEM CO LTD | 2000-04-25 | — | — | JP | disclosed |
| WO-2000009508-A1 | TRIAZOLOPYRIMIDINE DERIVATIVES | NIHON BAYER AGROCHEM K.K. (DE) | 2000-02-24 | — | — | WO | disclosed |