SCHEMBL8007958

SCHEMBL8007958

O=C(O)c1ccc(Cl)c(S(=O)O)c1.[NaH].[NaH]

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.57
MAPT P10636 2/20 0.47
ALDH1A1 P00352 1/20 0.47
SRD5A2 P31213 4/20 0.46
ALOX15 P16050 1/20 0.42
TDP1 Q9NUW8 1/20 0.41
KMT2A Q03164 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
L3MBTL1 Q9Y468 2/20 0.39
TTR P02766 2/20 0.39
KDM4E B2RXH2 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
POLB P06746 1/20 0.39
GAA P10253 1/20 0.39
CA4 P22748 1/20 0.39
CA6 P23280 1/20 0.39
PTGS2 P35354 1/20 0.39
CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1495512 0.98 TSHR (0.59) TSHRMAPTALDH1A1SRD5A2ALOX15
SCHEMBL9436678 0.80 TSHR (0.55) TSHRMAPTALDH1A1SRD5A2ALOX15
SCHEMBL8007954 0.80 CA2 (0.47) TSHRCA1CA2CA4
SCHEMBL8068458 0.78 LMNA (0.43) TSHRMAPTSRD5A2ALOX15KMT2A
SCHEMBL8815953 0.78 HTT (0.41) TSHRMAPTALDH1A1SRD5A2TDP1
SCHEMBL9436585 0.78 TTR (0.48) TSHRMAPTALDH1A1SRD5A2ALOX15
SCHEMBL4847012 0.76 TSHR (0.95) TSHRMAPTALDH1A1SRD5A2ALOX15
SCHEMBL1495495 0.76 TSHR (0.47) TSHRMAPTALDH1A1SRD5A2ALOX15
SCHEMBL2762790 0.76 LMNA (0.44) TSHRMAPTSRD5A2ALOX15KMT2A
SCHEMBL8814202 0.76 HTT (0.41) TSHRMAPTALDH1A1SRD5A2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6022899-A EFFECTIVE INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 2000-02-08 US disclosed
US-5753710-A INHIBITORS OF THE CELLULAR SODIUM PROTON ANTIPORTER HOECHST AKTIENGESELLSCHAFT (DE) 1998-05-19 US disclosed
US-5292755-A USPA benzolyguanidines HOECHST AKTIENGESELLSCHAFT (DE) 1994-03-08 US disclosed
US-5091394-A BENZOYLGUANIDINES, A PROCESS FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND MEDICAMENTS CONTAINING THEM HOECHST AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed