Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 8/20 | 0.38 |
| ▸ | CA2 | P00918 | 8/20 | 0.38 |
| ▸ | CA5A | P35218 | 8/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 8/20 | 0.38 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7394045 | 0.93 | NAMPT (0.43) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| Arginine SCHEMBL7359466 | 0.90 | F10 (0.36) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| SCHEMBL27938888 | 0.79 | CA1 (0.46) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| Sarcosine SCHEMBL7358190 | 0.77 | SMN1; SMN2 (0.39) | NAMPTALDH1A1KMT2A | |
| SCHEMBL28077269 | 0.74 | F2 (0.53) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| Dl-Phenylalanine SCHEMBL27977539 | 0.70 | CYP1A2 (0.59) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| SCHEMBL27898662 | 0.70 | F2 (0.48) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| Sarcosine SCHEMBL7363936 | 0.69 | ALDH1A1 (0.58) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| SCHEMBL28190227 | 0.69 | CYP1A2 (0.54) | CYP1A2CYP2C19F2PRSS1PRSS2 | |
| SCHEMBL27977537 | 0.69 | CYP1A2 (0.54) | CYP1A2CYP2C19F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025472-A | PEPTIDE ALDEHYDES WHICH ARE POTENT INHIBITORS OF FACTOR XA, USEFUL AS THERAPEUTIC AGENTS FOR DISEASE STATES IN MAMMALS CHARACTERIZED BY ABNORMAL THROMBOSIS | CORVAS INTERNATIONAL, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5696231-A | ANTICOAGULANTS; CARDIOVASCULAR DISORDERS | CORVAS INTERNATIONAL, INC. (US) | 1997-12-09 | — | — | US | disclosed |
| EP-0801654-A1 | N-SUBSTITUTED GLYCINE DERIVATIVES AS INHIBITORS OF FACTOR Xa | CORVAS INTERNATIONAL, INC. (US) | 1997-10-22 | — | — | EP | disclosed |