Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196642 | 0.89 | GAA (0.47) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL30823916 | 0.89 | GAA (0.47) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL29414570 | 0.89 | GAA (0.47) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL232686 | 0.87 | GAA (0.54) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| Sulfuric Acid SCHEMBL29203961 | 0.86 | MEN1 (0.44) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL4571018 | 0.85 | GAA (0.52) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL4571024 | 0.85 | GAA (0.52) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL9644871 | 0.85 | GAA (0.44) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| Sulfuric Acid SCHEMBL17416113 | 0.84 | SMN1; SMN2 (0.39) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 | |
| SCHEMBL4417312 | 0.84 | SMN1; SMN2 (0.42) | GAASMN1; SMN2BRPF1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2820145-B1 | MEANS AND METHODS FOR THE DETERMINATION OF (D)-2-HYDROXYGLUTARATE (D2HG) OR (D)-2-HYDROXYADIPIC ACID | DEUTSCHES KREBSFORSCH (DE) | 2016-05-25 | — | — | EP | claimed |
| EP-0971037-A2 | Stable reagent for formazan-based assay | Kirkegaard & Perry Laboratories, Inc. (US) | 2000-01-12 | — | — | EP | claimed |
| US-4176026-A | Process for catalytic photo-oxidation of water | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1979-11-27 | — | — | US | claimed |
| CN-1322254-A | Small volume in vitro analytical sensor containing diffusible or non-leachable redox mediator | THERASENSE INC (US) | 2001-11-14 | — | — | CN | disclosed |
| US-5445943-A | Reduction of an aromatic nitrosoaniline compound to a colored quinone diimine | BOEHRINGER MANNHEIM GMBH (DE) | 1995-08-29 | — | — | US | disclosed |
| US-4211621-A | Method and apparatus for producing hydrogen using solar energy | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1980-07-08 | — | — | US | disclosed |
| US-4176026-A | Process for catalytic photo-oxidation of water | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1979-11-27 | — | — | US | disclosed |