Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.34 |
| ▸ | DDX3X | O00571 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGAV | P06756 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8008599 | 1.00 | KMT2A (0.34) | KMT2APTGS2KAT8DDX3XITGB3 | |
| SCHEMBL8009132 | 0.91 | PLA2G7 (0.35) | KMT2ANR3C1MEN1ALDH1A1MAPT | |
| SCHEMBL8009130 | 0.91 | PLA2G7 (0.35) | KMT2ANR3C1MEN1ALDH1A1MAPT | |
| SCHEMBL6953049 | 0.89 | ALDH1A1 (0.39) | KMT2APTGS2KAT8DDX3XMEN1 | |
| SCHEMBL6953052 | 0.89 | ALDH1A1 (0.39) | KMT2APTGS2KAT8DDX3XMEN1 | |
| SCHEMBL8011511 | 0.88 | KMT2A (0.39) | KMT2AKAT8MEN1ALDH1A1MAPT | |
| SCHEMBL8011510 | 0.88 | KMT2A (0.39) | KMT2AKAT8MEN1ALDH1A1MAPT | |
| SCHEMBL8008609 | 0.86 | KMT2A (0.37) | KMT2AKAT8MEN1ALDH1A1MAPT | |
| SCHEMBL8008612 | 0.86 | KMT2A (0.37) | KMT2AKAT8MEN1ALDH1A1MAPT | |
| SCHEMBL8009327 | 0.86 | MAPT (0.37) | KMT2AMEN1ALDH1A1MAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | claimed |
| US-6034099-A | Method for inhibiting neoplastic lesions by administering 4-(arylmethylene)- 2, 3- dihydro-pyrazol-3-ones | CELL PATHWAYS, INC. (US) | 2000-03-07 | — | — | US | disclosed |