SCHEMBL8009328

SCHEMBL8009328

Oc1c(-c2ccsc2)c[c]cc1-c1ccsc1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TMIGD3 P0DMS9 2/20 0.41
ADORA2A P29274 2/20 0.41
ADORA1 P30542 2/20 0.41
CYP2A6 P11509 4/20 0.40
CYP2B6 P20813 2/20 0.40
CYP2E1 P05181 1/20 0.40
PELI1 Q96FA3 2/20 0.39
TDO2 P48775 1/20 0.38
CYP3A4 P08684 1/20 0.37
CYP2C9 P11712 1/20 0.37
CYP2C19 P33261 1/20 0.37
ERN1 O75460 3/20 0.37
ACMSD Q8TDX5 1/20 0.36
TOP2A P11388 1/20 0.35
GPR35 Q9HC97 2/20 0.35
KCNH2 Q12809 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5924659 0.71 CYP2A6 (0.56) CYP2A6CYP2B6CYP2E1CYP3A4CYP2C9
SCHEMBL7995665 0.69 ERN1 (0.50) TMIGD3ADORA2AADORA1CYP2A6PELI1
SCHEMBL22734811 0.69 CYP2A6 (0.52) CYP2A6CYP2B6CYP2E1PELI1TDO2
SCHEMBL27734030 0.69 BACE1 (0.50) CYP2A6
SCHEMBL4946960 0.67 CYP2A6 (0.64) TMIGD3ADORA2AADORA1CYP2A6CYP2B6
SCHEMBL9598459 0.67 CYP2A6 (0.33) CYP2A6CYP2B6CYP2E1TDO2CYP3A4
SCHEMBL277051 0.67 PELI1 (0.50) TMIGD3ADORA2AADORA1CYP2A6CYP2B6
SCHEMBL28445787 0.67 KCNH2 (0.43) ADORA2AADORA1CYP2A6CYP2B6CYP2E1
SCHEMBL6763494 0.67 ERN1 (0.44) TMIGD3ADORA2AADORA1CYP2A6CYP2B6
SCHEMBL29431673 0.67 TMIGD3 (0.48) TMIGD3ADORA2AADORA1CYP2A6PELI1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6063815-A TREATMENT OF METABOLIC DISORDERS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-05-16 US disclosed