Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | TP53 | P04637 | 3/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009353 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL3138518 | 1.00 | ALDH1A1 (0.65) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL9840140 | 0.87 | TSHR (0.50) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL30277376 | 0.86 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL11871495 | 0.86 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL1357057 | 0.86 | ALDH1A1 (0.62) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL3123349 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL15613979 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL7279015 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 | |
| SCHEMBL29847574 | 0.84 | ALDH1A1 (0.59) | ALDH1A1TP53TSHRHIF1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015004485-A1 | THERAPEUTIC COMPOUNDS | ISIS INNOVATION LIMITED (GB) | 2015-01-15 | — | — | WO | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |