Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 8/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 6/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 4/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 3/20 | 0.46 |
| ▸ | CFB | P00751 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8024286 | 0.84 | ADRA2A (0.54) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL5827504 | 0.76 | HTR1D (0.66) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| Flutonidine SCHEMBL29367926 | 0.76 | ADRA2A (0.63) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL8020019 | 0.72 | ADRA2A (1.00) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL6173769 | 0.71 | NPC1 (0.51) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL11762970 | 0.71 | ADRA2A (0.63) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL29349477 | 0.71 | ADRA2A (0.63) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| Hydrochloric Acid SCHEMBL5828141 | 0.70 | NPC1 (0.50) | ADRA2AADRA1AADRA2CADRA2BADRA1D | |
| SCHEMBL8009991 | 0.68 | MAPK1 (0.35) | LMNA | |
| SCHEMBL13017190 | 0.68 | ADRA2A (0.66) | ADRA2AADRA1AADRA2CADRA2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0971900-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998042679-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION AND APPLICATION THEREOF IN THERAPY | SANOFI-SYNTHELABO (FR) | 1998-10-01 | — | — | WO | disclosed |