Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5828141 | 0.99 | NPC1 (0.50) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL5827404 | 0.94 | NPC1 (0.50) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5827392 | 0.93 | NPC1 (0.49) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL6174219 | 0.88 | SMN1; SMN2 (0.59) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5827423 | 0.87 | SMN1; SMN2 (0.58) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL12870032 | 0.76 | ACHE (0.76) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL11757404 | 0.76 | ADRA2A (0.63) | MEN1KMT2AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL1143175 | 0.76 | ACHE (0.74) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL30577265 | 0.75 | SMN1; SMN2 (0.81) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL3172131 | 0.75 | CFB (0.49) | MEN1KMT2AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170288-B9 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2005-01-26 | — | — | EP | disclosed |
| EP-1170288-B1 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | SERVIER LAB (FR) | 2004-08-11 | — | — | EP | disclosed |
| EP-1170288-A2 | Diphenylureum derivatives and their use as alpha2/5-HT2c antagonists | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |