Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.74 |
| ▸ | HTR2A | P28223 | 6/20 | 0.74 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 5/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8576957 | 0.91 | DRD2 (0.67) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL7439064 | 0.91 | DRD2 (0.83) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL19838801 | 0.88 | HTR2A (0.71) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL19838782 | 0.88 | HTR2A (0.71) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL19852225 | 0.85 | HTR2A (1.00) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL5317315 | 0.83 | HTR2A (0.64) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL7326095 | 0.82 | SIGMAR1 (1.00) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL19852123 | 0.81 | SIGMAR1 (0.64) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL19852361 | 0.79 | DRD2 (0.59) | DRD2HTR2ASIGMAR1ADRA1DADRA1A | |
| SCHEMBL29964326 | 0.79 | SIGMAR1 (0.61) | DRD2HTR2ASIGMAR1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | claimed |
| US-6090808-A | PSYCHOLOGICAL DISORDERS; ANTICONVULSANTS | H. LUNDBECK A/S (DK) | 2000-07-18 | — | — | US | disclosed |
| US-6054580-A | STERICALLY HINDERED CROWN COMPOUND LIGAND FOR COMPLEXING WITH TRANSITION METAL AS OXIDATION CATALYST RESISTANT TO OXIDIZER DURING USE | CARNEGIE MELLON UNIVERSITY (US) | 2000-04-25 | — | — | US | disclosed |
| EP-0649407-B1 | DIMERIC PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES | LUNDBECK & CO AS H (DK) | 1998-08-05 | — | — | EP | disclosed |
| US-5658921-A | POTENT SIGMA RECEPTOR LIGANDS; WATER SOLUBILITY; SYMMETRY | H. LUNDBECK A/S (DK) | 1997-08-19 | — | — | US | disclosed |