Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 12/20 | 0.60 |
| ▸ | DRD3 | P35462 | 8/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 3/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3121989 | 0.92 | DRD2 (0.67) | DRD2DRD3ADRA1AKCNH2HTR1A | |
| SCHEMBL978209 | 0.87 | DRD2 (0.58) | DRD2DRD3ADRA1AHTR1A | |
| SCHEMBL977564 | 0.86 | DRD2 (0.58) | DRD2DRD3ADRA1AHTR1AHTR2A | |
| SCHEMBL976546 | 0.86 | DRD2 (0.57) | DRD2DRD3ADRA1AKCNH2HTR1A | |
| SCHEMBL27352770 | 0.84 | DRD3 (0.61) | DRD2DRD3ADRA1AKCNH2HTR1A | |
| SCHEMBL28007048 | 0.83 | HRH3 (0.54) | DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL6506385 | 0.82 | CYP1A2 (0.57) | DRD2DRD3ADRA1A | |
| SCHEMBL976063 | 0.82 | ADRA1A (0.73) | DRD2DRD3ADRA1AKCNH2HTR1A | |
| SCHEMBL31690833 | 0.82 | HRH3 (0.56) | DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL4616926 | 0.81 | ADRA1A (0.62) | DRD2DRD3ADRA1AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |
| EP-0512755-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1994-12-14 | — | — | EP | disclosed |