Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 6/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29818154 | 0.88 | ALDH1A1 (0.54) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818042 | 0.88 | ALDH1A1 (0.54) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27040083 | 0.86 | MAPT (0.58) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818048 | 0.84 | NPC1 (0.71) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818190 | 0.83 | DGAT1 (0.56) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818229 | 0.81 | NPC1 (0.62) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818284 | 0.80 | DGAT1 (0.53) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29817936 | 0.80 | MAPT (0.66) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818096 | 0.80 | MAPT (0.49) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29818159 | 0.79 | DGAT1 (0.52) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975605-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | claimed |
| WO-1998046574-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-22 | — | — | WO | claimed |
| EP-0975605-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046574-A1 | PYRIDAZINE AND PHTHALAZINE DERIVATIVES, PROCESS OF THEIR PREPARATION AND THEIR USE AS ANTICONVULSANTS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-22 | — | — | WO | disclosed |