Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | MEN1 | O00255 | 7/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 7/20 | 1.00 |
| ▸ | HTT | P42858 | 6/20 | 1.00 |
| ▸ | HKDC1 | Q2TB90 | 6/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | CDC25A | P30304 | 1/20 | 1.00 |
| ▸ | CDC25B | P30305 | 1/20 | 1.00 |
| ▸ | CDC25C | P30307 | 1/20 | 1.00 |
| ▸ | MPI | P34949 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 7/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.83 |
| ▸ | CASP3 | P42574 | 3/20 | 0.83 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.83 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.83 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.83 |
| ▸ | APAF1 | O14727 | 3/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL299444 | 0.85 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL801218 | 0.84 | MAPT (0.72) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13076407 | 0.83 | MAPT (0.71) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL801236 | 0.82 | MAPT (0.69) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL290290 | 0.82 | PDF (1.00) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL290276 | 0.82 | PDF (0.70) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL13076408 | 0.81 | MAPT (0.68) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL298938 | 0.79 | MAPT (0.72) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL299173 | 0.79 | PDF (0.69) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL805350 | 0.79 | MAPT (0.64) | MAPTALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9909160-B2 | Modulators of alpha-synuclein toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-03-06 | — | — | US | disclosed |
| US-9879257-B2 | Modulators of alpha-synuclein toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160215321-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2016-07-28 | — | — | US | disclosed |
| US-20160046933-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH | 2016-02-18 | — | — | US | disclosed |
| US-9249444-B2 | Modulators of alpha-synuclein toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2016-02-02 | — | — | US | disclosed |
| EP-2959898-A1 | 4,5-DIOXO-NAPHTHO[1,2-b]FURANS AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2015-12-30 | — | — | EP | disclosed |
| US-9018003-B2 | Modulators of alpha-synuclein toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2015-04-28 | — | — | US | disclosed |
| US-20140051091-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2014-02-20 | — | — | US | disclosed |
| US-8501465-B2 | Modulators of alpha-synuclein toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2012-03-22 | — | — | US | disclosed |
| US-20110064722-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | Whitehead Institute for Miomedical Reasearch (US) | 2011-03-17 | — | — | US | disclosed |
| WO-2010129049-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2010-11-11 | — | — | WO | disclosed |
| US-20090304664-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2009-12-10 | — | — | US | disclosed |
| EP-1888095-A4 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2009086306-A1 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2009-07-09 | — | — | WO | disclosed |
| EP-1888095-A2 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006124892-A2 | MODULATORS OF ALPHA-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071523-A1 | BENZOFURAN-4,5-DIONES AS SELECTIVE PEPTIDE DEFORMYLASE INHIBITORS | PDF, EIF5B, EIF4E | MAPT 3128/4885ALDH1A1 3464/4885MEN1 2230/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.