⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7848848 | 0.67 | KDM4E (0.40) | — | |
| SCHEMBL7822661 | 0.67 | AKR1B1 (0.40) | — | |
| SCHEMBL7830747 | 0.67 | HDAC6 (0.43) | — | |
| SCHEMBL7822287 | 0.65 | ACHE (0.35) | — | |
| SCHEMBL7180368 | 0.64 | PARP10 (0.44) | — | |
| SCHEMBL7819618 | 0.63 | ACP3 (0.41) | — | |
| SCHEMBL8555103 | 0.61 | PIM1 (0.46) | — | |
| SCHEMBL7843220 | 0.61 | CHRNB2 (0.53) | — | |
| SCHEMBL7847650 | 0.61 | ACHE (0.34) | — | |
| SCHEMBL1582845 | 0.60 | CYP19A1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6100264-A | 5H, 10H-imidazo [1,2-A] indeno [1,2-E] pyrazin-4-one derivatives, their preparation, their intermediates and medicaments containing them | RHONE-POULENC RORER, S.A. (FR) | 2000-08-08 | — | — | US | disclosed |
| US-5990108-A | USEFUL AS ANTAGONISTS OF THE ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID (AMPA) RECEPTOR, ALSO KNOWN AS THE QUISQUALATE RECEPTOR, AND AS ANTAGONISTS OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR | RHONE POULENC RORER S.A. (FR) | 1999-11-23 | — | — | US | disclosed |