Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL842056 | 0.93 | SMYD3 (0.45) | EPHX1SIGMAR1METAP2KDM4EEPHX2 | |
| SCHEMBL2362012 | 0.93 | SMYD3 (0.45) | EPHX1SIGMAR1METAP2KDM4EEPHX2 | |
| Hydrochloric Acid SCHEMBL14974708 | 0.91 | SMYD3 (0.44) | EPHX1SIGMAR1METAP2EPHX2SMYD3 | |
| Hydrochloric Acid SCHEMBL2377127 | 0.91 | SMYD3 (0.44) | EPHX1SIGMAR1METAP2EPHX2SMYD3 | |
| Hydrochloric Acid SCHEMBL2376124 | 0.91 | SMYD3 (0.44) | EPHX1SIGMAR1METAP2EPHX2SMYD3 | |
| SCHEMBL8491681 | 0.87 | SMN1; SMN2 (0.46) | EPHX1SIGMAR1METAP2KDM4EALDH1A1 | |
| SCHEMBL8006760 | 0.84 | SIGMAR1 (0.51) | EPHX1SIGMAR1METAP2EPHX2 | |
| SCHEMBL8492486 | 0.84 | SIGMAR1 (0.51) | EPHX1SIGMAR1METAP2EPHX2 | |
| SCHEMBL5674754 | 0.83 | ANPEP (0.51) | EPHX1METAP2KDM4E | |
| SCHEMBL13338123 | 0.83 | SMN1; SMN2 (0.42) | EPHX1SIGMAR1METAP2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117870-A | USEFUL AS THERAPEUTIC DRUG OR PREVENTIVE DRUG OF ARTHRITIS AND RHEUMATISM DUE TO INCREASE OF BONE RESORPTION IN ADDITION TO BONE DISEASES SUCH AS OSTEOPOROSIS, HYPERCALCEMIA, AND PAGET'S DISEASE | FUJIREBIO KABUSHIKI KAISHA (JP) | 2000-09-12 | — | — | US | disclosed |