Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 7/20 | 0.71 |
| ▸ | BCHE | P06276 | 6/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.71 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | GFER | P55789 | 2/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7944432 | 0.86 | BCHE (0.65) | ACHEBCHEAPPKDM4EMEN1 | |
| SCHEMBL7935378 | 0.80 | ACHE (0.60) | ACHEBCHEAPP | |
| SCHEMBL8018033 | 0.78 | BCHE (0.58) | ACHEBCHEAPP | |
| SCHEMBL7944938 | 0.77 | HRH3 (0.67) | ACHEBCHERAD52 | |
| SCHEMBL7935359 | 0.77 | BCHE (0.61) | ACHEBCHEAPPKDM4EMEN1 | |
| SCHEMBL7941639 | 0.76 | ACHE (0.61) | ACHEBCHEGAAGFERAPP | |
| SCHEMBL8020560 | 0.76 | BCHE (0.60) | ACHEBCHEAPPKDM4EMEN1 | |
| SCHEMBL8014300 | 0.75 | HRH3 (0.69) | ACHEBCHERAD52 | |
| SCHEMBL7944443 | 0.75 | BCHE (0.57) | ACHEBCHEAPP | |
| SCHEMBL7944955 | 0.75 | BCHE (0.61) | ACHEBCHEGAAGFERAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6075144-A | ABILITY TO INHIBIT ACETYLCHOLINESTERASE; TREATS ALZHEIMER,S DISEASE | HOECHST MARION ROUSSEL, INC. (US) | 2000-06-13 | — | — | US | claimed |