SCHEMBL8014114

SCHEMBL8014114

O=C(NC(=O)c1ccccc1F)Nc1cc(C(F)(F)F)c(Cl)cc1Br

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.50
PYGL P06737 4/20 0.45
TP53 P04637 1/20 0.45
NPC1 O15118 3/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 3/20 0.42
HPGD P15428 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
KCNMA1 Q12791 1/20 0.42
MAPT P10636 2/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
GRM4 Q14833 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
PPIA P62937 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8013451 0.91 SMN1; SMN2 (0.54) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL8014718 0.91 KDM4E (0.53) PYGLNPC1RAB9ASMN1; SMN2KDM4E
SCHEMBL8011337 0.90 PYGL (0.47) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL8011785 0.90 PYGL (0.47) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL8011755 0.87 MEN1 (0.57) TRPV1NPC1KDM4EALDH1A1KMT2A
SCHEMBL8014705 0.86 KDM4E (0.51) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL8010693 0.84 KDM4E (0.53) PYGLTP53NPC1RAB9ASMN1; SMN2
SCHEMBL8419795 0.80 TRPV1 (0.59) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL10782418 0.79 TRPV1 (0.49) TRPV1PYGLNPC1RAB9ASMN1; SMN2
SCHEMBL10631064 0.78 MEN1 (0.57) TRPV1PYGLNPC1KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0939753-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME Dongbu Hannong Chemical Co., Ltd. (KR) 1999-09-08 EP claimed
WO-1997024321-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME HANWHA CORPORATION (KR) 1997-07-10 WO claimed
US-6051737-A AS PESTICIDE DONGBU HANNONG CHEMICAL, CO. LTD. (KR) 2000-04-18 US disclosed
EP-0939753-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME Dongbu Hannong Chemical Co., Ltd. (KR) 1999-09-08 EP disclosed
WO-1997024321-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME HANWHA CORPORATION (KR) 1997-07-10 WO disclosed