SCHEMBL8419795

SCHEMBL8419795

O=C(NC(=O)c1ccccc1F)Nc1cc(C(F)(F)F)cc(Cl)c1Br

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 1/20 0.59
PYGL P06737 3/20 0.45
TP53 P04637 1/20 0.45
TLR8 Q9NR97 1/20 0.45
NPC1 O15118 2/20 0.44
RAB9A P51151 1/20 0.44
KDM4E B2RXH2 4/20 0.43
HPGD P15428 3/20 0.43
GAA P10253 2/20 0.43
TLR7 Q9NYK1 1/20 0.43
ALDH1A1 P00352 3/20 0.42
KMT2A Q03164 3/20 0.42
MEN1 O00255 2/20 0.42
KCNMA1 Q12791 1/20 0.42
MAPT P10636 2/20 0.41
USP2 O75604 1/20 0.41
ALOX15 P16050 1/20 0.41
P2RX1 P51575 1/20 0.41
P2RX7 Q99572 1/20 0.41
TDP1 Q9NUW8 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9119083 0.87 TRPV1 (0.51) TRPV1PYGLTLR8NPC1RAB9A
SCHEMBL7752523 0.85 TRPV1 (0.57) TRPV1PYGLTLR8NPC1RAB9A
SCHEMBL9118302 0.82 KDM4E (0.51) TRPV1PYGLNPC1RAB9AKDM4E
SCHEMBL8014114 0.80 TRPV1 (0.50) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL8840201 0.79 NPC1 (0.50) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL7748808 0.77 SMN1; SMN2 (0.52) TRPV1PYGLTP53NPC1RAB9A
SCHEMBL10782418 0.77 TRPV1 (0.49) TRPV1PYGLNPC1RAB9AKDM4E
SCHEMBL7752690 0.77 KDM4E (0.53) TRPV1PYGLNPC1RAB9AKDM4E
SCHEMBL9119160 0.77 SMN1; SMN2 (0.54) PYGLNPC1RAB9AHPGDGAA
SCHEMBL8011785 0.75 PYGL (0.47) TRPV1PYGLTP53NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0939753-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME Dongbu Hannong Chemical Co., Ltd. (KR) 1999-09-08 EP claimed
WO-1997024321-A1 ARYL BENZOYL UREA DERIVATIVE AND PESTICIDAL COMPOSITION COMPRISING THE SAME HANWHA CORPORATION (KR) 1997-07-10 WO claimed