⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1866638 | 0.72 | — | — | |
| SCHEMBL9010330 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL10912090 | 0.71 | — | — | |
| SCHEMBL1867434 | 0.65 | CYP3A4 (0.34) | — | |
| SCHEMBL8922730 | 0.64 | — | — | |
| SCHEMBL2016299 | 0.62 | — | — | |
| SCHEMBL7831061 | 0.61 | — | — | |
| SCHEMBL12494175 | 0.61 | MAPT (0.36) | — | |
| SCHEMBL7616396 | 0.58 | — | — | |
| SCHEMBL7797827 | 0.58 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996035422-A1 | METHODS FOR INHIBITING BONE LOSS | ELI LILLY AND COMPANY (US) | 1996-11-14 | — | — | WO | claimed |
| EP-0969003-A2 | Process for the preparation of benzo[f]quinolinone derivatives and intermediates | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1999065878-A1 | SYNTHESIS OF BENZO[F]QUINOLINONES | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| WO-1998018757-A1 | SYNTHESIS OF BENZO[F]QUINOLINONES | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |
| US-5635197-A | BENZO(F)QUINOLIN-3-ONES; ANTICARCINOGENIC AGENTS; BONE DISORDERS | ELI LILLY AND COMPANY (US) | 1997-06-03 | — | — | US | disclosed |
| US-5622962-A | PROSTATE CANCER, SKIN DISORDERS, BALDNESS | ELI LILLY AND COMPANY (US) | 1997-04-22 | — | — | US | disclosed |
| US-5578724-A | INHIBITORS OF 5-ALPHA-REDUCTASE | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996035422-A1 | METHODS FOR INHIBITING BONE LOSS | ELI LILLY AND COMPANY (US) | 1996-11-14 | — | — | WO | disclosed |
| EP-0742010-A2 | Benzoquinolin-3-ones to inhibit bone loss | ELI LILLY AND COMPANY (US) | 1996-11-13 | — | — | EP | disclosed |
| US-5574160-A | Syntheis of benzoquinolinones | ELI LILLY AND COMPANY (US) | 1996-11-12 | — | — | US | disclosed |
| US-5550134-A | ADMINISTERING TO A MAMMAL FROM A SERIES OF BENZOQUINOLIN-3-ONE COMPOUNDS | ELI LILLY AND COMPANY (US) | 1996-08-27 | — | — | US | disclosed |
| US-5541190-A | TREATING BENIGN PROSTATIC HYPERPLASIA, MALE PATTERN BALDNESS, PROSTATIC CANCER, ANDROGENIC ALOPECIA | ELI LILLY AND COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| WO-1996009046-A1 | 5α-REDUCTASE INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-03-28 | — | — | WO | disclosed |
| US-5334767-A | Steroid 5a-reductase inhibitor | ELI LILLY AND COMPANY (US) | 1994-08-02 | — | — | US | disclosed |