Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 4/20 | 0.59 |
| ▸ | THRA | P10827 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | CCR6 | P51684 | 1/20 | 0.55 |
| ▸ | CYP24A1 | Q07973 | 6/20 | 0.53 |
| ▸ | CYP27A1 | Q02318 | 3/20 | 0.53 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592165 | 1.00 | METAP1 (0.59) | METAP1THRATHRBHSP90AA1CCR6 | |
| SCHEMBL28031701 | 0.87 | CYP26A1 (0.57) | METAP1THRATHRBCYP24A1CYP27A1 | |
| SCHEMBL8012038 | 0.86 | METAP1 (0.78) | METAP1THRATHRBHSP90AA1CCR6 | |
| SCHEMBL7590283 | 0.86 | METAP1 (0.78) | METAP1THRATHRBHSP90AA1CCR6 | |
| Hydrochloric Acid SCHEMBL10341505 | 0.85 | METAP1 (0.78) | METAP1THRATHRBHSP90AA1CCR6 | |
| SCHEMBL7590969 | 0.79 | METAP1 (0.74) | METAP1THRATHRBHSP90AA1CCR6 | |
| SCHEMBL11011369 | 0.79 | METAP1 (0.76) | METAP1THRATHRBHSP90AA1CCR6 | |
| Hydrochloric Acid SCHEMBL4623159 | 0.78 | METAP1 (0.78) | METAP1THRATHRBHSP90AA1CCR6 | |
| SCHEMBL2969421 | 0.77 | HSP90AA1 (0.55) | METAP1HSP90AA1CCR6 | |
| Hydrochloric Acid SCHEMBL6293297 | 0.76 | HSP90AA1 (0.57) | METAP1HSP90AA1CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6022895-A | Substituted amino compounds and their use as substances having an analgesic effect | GRUENENTHAL GMBH (DE) | 2000-02-08 | — | — | US | disclosed |