Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | TACR2 | P21452 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | PRCP | P42785 | 1/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031040 | 0.89 | MAOA (0.46) | MAOAGPR84CHRM2CHRM4CHRM5 | |
| SCHEMBL1009585 | 0.75 | MAOA (0.45) | MAOACHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8023881 | 0.75 | MAOA (0.57) | MAOAPLAUASIC3PRCP | |
| SCHEMBL8015279 | 0.74 | MAOA (0.47) | MAOAPLAUASIC3PRCP | |
| SCHEMBL8025234 | 0.73 | MAOA (0.49) | MAOAPLAUASIC3PRCP | |
| SCHEMBL8012551 | 0.73 | BRD4 (0.55) | — | |
| SCHEMBL8023234 | 0.72 | MAOA (0.48) | MAOAPLAUASIC3PRCP | |
| SCHEMBL8024957 | 0.71 | MAOA (0.47) | MAOAPLAUASIC3PRCP | |
| SCHEMBL8031039 | 0.70 | MAOA (0.49) | MAOA | |
| SCHEMBL8025942 | 0.70 | HTR1A (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |