Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | APLNR | P35414 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.30 |
| ▸ | THPO | P40225 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.30 |
| ▸ | GRM5 | P41594 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018708 | 1.00 | GRM4 (0.32) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL8018705 | 1.00 | GRM4 (0.32) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9565486 | 0.78 | GRM4 (0.31) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9565484 | 0.78 | GRM4 (0.31) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9025433 | 0.78 | GRM4 (0.35) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL8019500 | 0.78 | GRM4 (0.35) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9112825 | 0.63 | GRM4 (0.34) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9094844 | 0.63 | POLB (0.34) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9096914 | 0.63 | MAPT (0.35) | GRM4MEN1KMT2ACYP2C19ALDH1A1 | |
| SCHEMBL9754005 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025519-A | REACTING A DICARBOXYLIC ESTER WITH A KETENE ACETAL, CYCLIZATION; TRANS INTERMEDIATES IN THE SYNTHESIS OF PHARMACEUTICALLY ACTIVE DRUGS | LONZA, LTD. (CH) | 2000-02-15 | — | — | US | disclosed |