Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | GRM6 | O15303 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094844 | 0.75 | POLB (0.34) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL9094283 | 0.71 | BTK (0.41) | MEN1KMT2A | |
| SCHEMBL25038886 | 0.67 | APLNR (0.54) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8365729 | 0.66 | EPHX2 (0.33) | CYP2C19MEN1CYP1A2KMT2A | |
| SCHEMBL19271804 | 0.65 | EPHX2 (0.55) | ALDH1A1KMT2A | |
| SCHEMBL4335552 | 0.63 | GRM4 (0.44) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8015707 | 0.63 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8018705 | 0.63 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8018708 | 0.63 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL28674229 | 0.62 | GRM4 (0.35) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677039-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | Abbott Laboratories (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995012572-A1 | CYCLOBUTANE DERIVATIVES AS INHIBITORS OF SQUALENE SYNTHETASE AND PROTEIN FARNESYLTRANSFERASE | ABBOTT LABORATORIES (US) | 1995-05-11 | — | — | WO | disclosed |