Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 4/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GRM8 | O00222 | 1/20 | 0.35 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.31 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019500 | 1.00 | GRM4 (0.35) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8018708 | 0.78 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8015707 | 0.78 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL8018705 | 0.78 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL9565510 | 0.74 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL9565506 | 0.74 | GRM4 (0.32) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL9096914 | 0.71 | MAPT (0.35) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL31104772 | 0.67 | APLNR (0.34) | CYP2C19APLNR | |
| SCHEMBL4335552 | 0.65 | GRM4 (0.44) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 | |
| SCHEMBL9094264 | 0.65 | GRM4 (0.50) | GRM4CYP2C19MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458643-B1 | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | SQUIBB & SONS INC (US) | 1995-11-29 | — | — | EP | claimed |
| US-5344962-A | Intermediates in the synthesis of an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1994-09-06 | — | — | US | claimed |
| EP-0458643-A2 | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | E.R. SQUIBB & SONS, INC. (US) | 1991-11-27 | — | — | EP | claimed |
| EP-0458363-B1 | Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines | SQUIBB & SONS INC (US) | 1996-02-07 | — | — | EP | disclosed |
| EP-0458643-B1 | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | SQUIBB & SONS INC (US) | 1995-11-29 | — | — | EP | disclosed |
| US-5344962-A | Intermediates in the synthesis of an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1994-09-06 | — | — | US | disclosed |
| EP-0554025-A2 | Fluorinated cyclobutyl purines and pyrimidines | E.R. SQUIBB & SONS, INC. (US) | 1993-08-04 | — | — | EP | disclosed |
| US-5233076-A | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | E. R. SQUIBB & SONS, INC. (US) | 1993-08-03 | — | — | US | disclosed |
| WO-1991018969-A1 | FLUORINATED BIS(HYDROXYMETHYL)CYCLOBUTYL PURINES AND PYRIMIDINES | E.R. SQUIBB & SONS, INC. (US) | 1991-12-12 | — | — | WO | disclosed |
| EP-0458363-A1 | Fluorinated bis(hydroxymethyl) cyclobutyl purines and pyrimidines | E.R. SQUIBB & SONS, INC. (US) | 1991-11-27 | — | — | EP | disclosed |
| EP-0458643-A2 | Process for preparing an optically active cyclobutanone, an intermediate in the synthesis of an optically active cyclobutane nucleoside | E.R. SQUIBB & SONS, INC. (US) | 1991-11-27 | — | — | EP | disclosed |