Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.48 |
| ▸ | LATS1 | O95835 | 11/20 | 0.47 |
| ▸ | LATS2 | Q9NRM7 | 8/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL805529 | 0.86 | ACP1 (0.50) | GRM4LATS1LATS2KDRKDM4E | |
| SCHEMBL802049 | 0.83 | GRM4 (0.53) | GRM4KDRPIM1PIM2KDM4E | |
| SCHEMBL801656 | 0.81 | GSK3B (0.58) | LATS1LATS2GSK3AGSK3B | |
| SCHEMBL802274 | 0.81 | PIK3CA (0.42) | GRM4PIK3CA | |
| SCHEMBL801863 | 0.81 | LATS1 (0.49) | LATS1LATS2GSK3AGSK3BALDH1A1 | |
| SCHEMBL802671 | 0.80 | FADS1 (0.41) | GRM4ALDH1A1CYP1A2SMN1; SMN2PIK3CA | |
| SCHEMBL802337 | 0.77 | GRM4 (0.45) | GRM4GSK3BTGFBR1KDM4EALDH1A1 | |
| SCHEMBL802329 | 0.76 | VCP (0.38) | GRM4KDM4EALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL802674 | 0.75 | GSK3A (0.44) | GRM4GSK3AGSK3BALDH1A1CYP1A2 | |
| SCHEMBL801648 | 0.75 | SYK (0.44) | GRM4KDRALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633210-B2 | Triazole compounds useful as protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-01-21 | — | — | US | disclosed |
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071657-A1 | TRIAZOLE COMPOUNDS USEFUL AS PROTEIN KINASE INHIBITORS | GSK3B, GSK3A, CDK19 | GRM4 3726/4885LATS1 1086/4885LATS2 1373/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.