Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.54 |
| ▸ | IGF1R | P08069 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 3/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2058979 | 0.85 | CYP2C19 (0.64) | SLC6A3CYP2C19CNR2NR3C1CYP1A2 | |
| SCHEMBL6313150 | 0.81 | INSR (0.65) | INSRIGF1RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7838397 | 0.81 | SLC6A2 (0.51) | INSRIGF1RSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL6675829 | 0.76 | BCHE (0.59) | SLC6A2SLC6A4SLC6A3CYP2C19CNR2 | |
| SCHEMBL29764499 | 0.76 | BCHE (0.59) | SLC6A2SLC6A4SLC6A3CYP2C19CNR2 | |
| SCHEMBL2960872 | 0.75 | CYP2C19 (0.78) | SLC6A3CYP2C19CNR2NR3C1CYP1A2 | |
| SCHEMBL8013362 | 0.75 | TSHR (0.75) | CYP2C19CNR2TSHRNR1H2NR1H3 | |
| SCHEMBL17266146 | 0.73 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3CYP2C19BCHE | |
| SCHEMBL7689432 | 0.72 | CYP2C19 (0.49) | SLC6A3CYP2C19CNR2NR3C1CYP1A2 | |
| SCHEMBL4407604 | 0.72 | CYP2C19 (0.67) | SLC6A3CYP2C19CNR2NR3C1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117893-A | Heterocyclic compounds having anti-diabetic activity and their use | SANKYO COMPANY, LIMITED (JP) | 2000-09-12 | — | — | US | disclosed |
| US-5977365-A | HYPOGLYCEMIC AGENTS | SANKYO COMPANY, LIMITED (JP) | 1999-11-02 | — | — | US | disclosed |
| US-5624935-A | ANTIDIABETIC AGENTS, HYPOGLYCEMIC AGENTS OR ANTILIPEMIC AGENTS | SANKYO COMPANY, LIMITED | 1997-04-29 | — | — | US | disclosed |
| EP-0676398-A2 | Heterocyclic compounds having anti-diabetic activity, their preparation and their use | SANKYO COMPANY LIMITED (JP) | 1995-10-11 | — | — | EP | disclosed |