Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651614 | 0.81 | HPGD (0.48) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL29782139 | 0.81 | HPGD (0.48) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL14638820 | 0.76 | TSHR (0.41) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL8021009 | 0.76 | PARP1 (0.53) | MAPTKDM4EMEN1NPC1PKM | |
| SCHEMBL3184435 | 0.72 | TSHR (0.70) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL6322177 | 0.72 | SRD5A2 (0.79) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL14638735 | 0.72 | TSHR (0.47) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL9448906 | 0.72 | TSHR (0.52) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL3319687 | 0.70 | TSHR (0.67) | TSHRSRD5A2MAPTKDM4EMEN1 | |
| SCHEMBL8352471 | 0.70 | TSHR (1.00) | TSHRSRD5A2MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0973720-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-01-26 | — | — | EP | disclosed |
| WO-1998040344-A1 | 2-SUBSTITUTED BENZOYL-CYCLOALKYL-1-CARBOXYLIC ACID DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1998-09-17 | — | — | WO | disclosed |