SCHEMBL8018102

SCHEMBL8018102

CNC(=O)c1ccc(/C=C/C(=O)C(N)c2cccn2-c2ccc(Cl)c(COc3cccc4c3nc(OC)n4OCc3ccccn3)c2Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7014797 0.89 BDKRB2 (0.62) BDKRB2
SCHEMBL8018110 0.87 BDKRB2 (0.68) BDKRB2
SCHEMBL8018105 0.87 BDKRB2 (0.68) BDKRB2
SCHEMBL8017675 0.84 BDKRB2 (0.64) BDKRB2
SCHEMBL7011669 0.82 BDKRB2 (0.61) BDKRB2
SCHEMBL8011048 0.82 BDKRB2 (0.55) BDKRB2
SCHEMBL7014258 0.81 BDKRB2 (0.73) BDKRB2
SCHEMBL7017869 0.81 BDKRB2 (0.64) BDKRB2
SCHEMBL7010161 0.81 BDKRB2 (0.61) BDKRB2
Hydrochloric Acid SCHEMBL7015839 0.81 BDKRB2 (0.74) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6127389-A TREATMENT OF HYPERTENSION, RENAL DISEASES, HEART FAILURE, HYPERTENSION, MENIERE'S DISEASE, PERIPHERAL AND CEREBRAL CIRCULATORY DISORDERS, CLIMACTERIC DISTURBANCE, RETINOCHOROIDAL CIRCULATORY DISORDERS, MYOCARDIAL ISCHEMIA FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-10-03 US disclosed
US-6015818-A TREATING KIDNEY, BRAIN, AND CARDIOVASCULAR DISORDERS; HYPOTENSIVE AGENTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2000-01-18 US disclosed