Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.79 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.79 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.79 |
| ▸ | TSHR | P16473 | 6/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.52 |
| ▸ | MEN1 | O00255 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8018088 | 1.00 | OPRM1 (0.79) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8018087 | 1.00 | OPRM1 (0.79) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8017118 | 0.94 | OPRK1 (0.69) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8011022 | 0.94 | OPRK1 (0.69) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8017120 | 0.94 | OPRK1 (0.69) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8017436 | 0.92 | OPRK1 (0.76) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8017432 | 0.92 | OPRK1 (0.76) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8024577 | 0.92 | OPRK1 (0.76) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8021585 | 0.90 | OPRM1 (0.63) | OPRM1OPRD1OPRK1TSHRALDH1A1 | |
| SCHEMBL8019880 | 0.90 | OPRM1 (0.63) | OPRM1OPRD1OPRK1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |