SCHEMBL8018992

SCHEMBL8018992

COC(=O)c1ccc(-c2nc3ccccc3nc2-c2ccc(C(=O)OC)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.60
KDM4E B2RXH2 5/20 0.60
HPGD P15428 4/20 0.60
SMN1; SMN2 Q16637 4/20 0.60
RAB9A P51151 4/20 0.60
NPC1 O15118 3/20 0.60
MAPT P10636 3/20 0.60
LMNA P02545 2/20 0.60
HSD17B10 Q99714 1/20 0.60
PKM P14618 1/20 0.60
NFKB1 P19838 1/20 0.60
NFKB2 Q00653 1/20 0.60
RELA Q04206 1/20 0.60
MAPK1 P28482 1/20 0.56
TNKS O95271 1/20 0.56
TSHR P16473 1/20 0.55
L3MBTL1 Q9Y468 2/20 0.53
NPSR1 Q6W5P4 1/20 0.53
TDP1 Q9NUW8 1/20 0.53
GAA P10253 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12111650 0.88 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL12111599 0.88 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL12111680 0.88 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL12111611 0.88 ALDH1A1 (0.61) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL30079151 0.87 CA1 (0.57) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL12111520 0.87 ALDH1A1 (0.55) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL12578243 0.84 ALDH1A1 (0.69) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL30072400 0.82 SMN1; SMN2 (0.50) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL8007062 0.82 RARA (0.61) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A
SCHEMBL15665951 0.81 ALDH1A1 (0.68) ALDH1A1KDM4EHPGDSMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0711803-B1 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LTD (JP) 2000-01-19 EP claimed
US-5651926-A SYNERGISTIC SUPPRESSION WITH CYCLIC IMINO ESTERS AND QUINOXALINES TEIJIN LIMITED (JP) 1997-07-29 US claimed
EP-0711803-A2 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LIMITED (JP) 1996-05-15 EP claimed
EP-0711803-B1 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LTD (JP) 2000-01-19 EP disclosed
US-5651926-A SYNERGISTIC SUPPRESSION WITH CYCLIC IMINO ESTERS AND QUINOXALINES TEIJIN LIMITED (JP) 1997-07-29 US disclosed
EP-0711803-A2 Method for preventing emission of fluorescence from polyalkylenenaphthalene-2,6-dicarboxylate TEIJIN LIMITED (JP) 1996-05-15 EP disclosed