Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 5/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | JUN | P05412 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NOS2 | P35228 | 5/20 | 0.49 |
| ▸ | NOS3 | P29474 | 4/20 | 0.49 |
| ▸ | NOS1 | P29475 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019022 | 1.00 | KDM4E (0.56) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8030398 | 1.00 | KDM4E (0.56) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8028606 | 1.00 | KDM4E (0.56) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8030407 | 1.00 | KDM4E (0.56) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8028624 | 0.92 | KDM4E (0.60) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8028620 | 0.92 | KDM4E (0.60) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8031841 | 0.82 | KDM4E (0.60) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8034404 | 0.78 | ALOX5 (0.79) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL13498777 | 0.77 | ALOX5 (0.68) | KDM4EMAPTHTTSMN1; SMN2JAK2 | |
| SCHEMBL8031865 | 0.77 | ALOX5 (0.68) | KDM4EMAPTHTTSMN1; SMN2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000063152-A1 | ACETYLATED AND RELATED ANALOGUES OF CHICORIC ACID AS HIV INTEGRASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-10-26 | — | — | WO | disclosed |