Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 12/20 | 0.79 |
| ▸ | JUN | P05412 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | FDPS | P14324 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24617861 | 0.92 | ALOX5 (0.74) | ALOX5JUNNFKB1KDM4EJAK2 | |
| SCHEMBL28181780 | 0.92 | ALOX5 (0.72) | ALOX5JUNNFKB1TTRKDM4E | |
| SCHEMBL15324915 | 0.91 | ALOX5 (0.73) | ALOX5JUNNFKB1KDM4EJAK2 | |
| SCHEMBL2602745 | 0.90 | TTR (0.74) | ALOX5NFKB1TTRKDM4EALDH1A1 | |
| SCHEMBL15378926 | 0.90 | TTR (0.74) | ALOX5NFKB1TTRKDM4EALDH1A1 | |
| SCHEMBL15384911 | 0.88 | ALOX5 (0.66) | ALOX5NFKB1TTRKDM4EALDH1A1 | |
| SCHEMBL13498777 | 0.87 | ALOX5 (0.68) | ALOX5JUNNFKB1KDM4EJAK2 | |
| SCHEMBL8031865 | 0.87 | ALOX5 (0.68) | ALOX5JUNNFKB1KDM4EJAK2 | |
| SCHEMBL7192753 | 0.86 | JUN (0.66) | ALOX5JUNNFKB1KDM4EJAK2 | |
| SCHEMBL15384910 | 0.84 | CA12 (0.67) | ALOX5JUNNFKB1TTRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000063152-A1 | ACETYLATED AND RELATED ANALOGUES OF CHICORIC ACID AS HIV INTEGRASE INHIBITORS | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2000-10-26 | — | — | WO | disclosed |