Leucine

Leucine

SCHEMBL8019054

CC(C)C[C@H](N)C(=O)O.O=C(O)[C@H](Cc1ccccc1)NF

nearest known ligand 0.59

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.59
ANPEP P15144 1/20 0.56
RNPEP Q9H4A4 1/20 0.56
DNPEP Q9ULA0 1/20 0.56
SLC1A3 P43003 1/20 0.54
SLC1A2 P43004 1/20 0.54
SLC1A1 P43005 1/20 0.54
SLC7A5 Q01650 2/20 0.53
ALPI P09923 1/20 0.53
PKM P14618 1/20 0.53
PTGS1 P23219 1/20 0.53
XIAP P98170 1/20 0.53
ACE P12821 1/20 0.52
MME P08473 1/20 0.51
MMP2 P08253 1/20 0.49
MMP7 P09237 1/20 0.49
MMP9 P14780 1/20 0.49
MMP12 P39900 1/20 0.49
MMP13 P45452 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL8740479 0.87 LTA4H (0.60) LTA4HANPEPRNPEPDNPEPSLC1A3
Leucine SCHEMBL5653346 0.84 LTA4H (0.56) LTA4HANPEPRNPEPDNPEPSLC1A3
Dl-Phenylalanine SCHEMBL31087886 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
D-Phenylalanine SCHEMBL10775923 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL28157585 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Dl-Phenylalanine SCHEMBL208388 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL2634732 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL10945389 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Phenylalanine SCHEMBL208389 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3
Dl-Phenylalanine SCHEMBL27551454 0.84 SLC7A5 (0.76) LTA4HANPEPRNPEPDNPEPSLC1A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6080542-A IDENTIFYING POLYNUCLEOTIDE THAT ENCODES A PLANT PEPTIDE TRANSPORT PROTEIN BY CULTURING TRANSFORMED PEPTIDE TRANSPORT-DEFICIENT SACCHAROMYCES STRAIN ON VARIOUS MEDIA AND SELECTING SURVIVORS BECKER JEFFREY M (US) 2000-06-27 US disclosed
EP-0767797-A4 PLANT PEPTIDE TRANSPORT GENE UNIV TENNESSEE RES CORP (US) 1998-06-10 EP disclosed
US-5689039-A HERBICIDE RESISTANCE THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1997-11-18 US disclosed
EP-0767797-A1 PLANT PEPTIDE TRANSPORT GENE THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1997-04-16 EP disclosed
WO-1995025114-A1 PLANT PEPTIDE TRANSPORT GENE THE UNIVERSITY OF TENNESSEE RESEARCH CORPORATION (US) 1995-09-21 WO disclosed