Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | PLAT | P00750 | 1/20 | 0.43 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.43 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694064 | 0.91 | PPARD (0.53) | FFAR1TNKS2PARP2PARP10FFAR4 | |
| SCHEMBL8695196 | 0.91 | FFAR1 (0.64) | FFAR1MTNR1AEDNRAFFAR4PPARG | |
| SCHEMBL8695194 | 0.81 | PPARD (0.58) | FFAR1FFAR4PPARGPPARDPPARA | |
| SCHEMBL3882956 | 0.79 | MAOB (0.56) | FFAR1PARP10FFAR4SPHK2SPHK1 | |
| SCHEMBL30656241 | 0.78 | FFAR1 (0.56) | FFAR1TNKS2PARP2EDNRAFFAR4 | |
| SCHEMBL8694056 | 0.75 | F9 (0.50) | FFAR1EDNRAPARP10FFAR4SPHK2 | |
| SCHEMBL30138881 | 0.75 | CYP2A6 (0.58) | MTNR1A | |
| SCHEMBL8905373 | 0.75 | CYP2A6 (0.58) | MTNR1A | |
| SCHEMBL6234342 | 0.74 | MAOB (0.51) | FFAR1TNKS2PARP2EDNRA | |
| SCHEMBL2912575 | 0.74 | FFAR1 (0.66) | FFAR1PARP10FFAR4SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745584-B1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-01-05 | — | — | EP | disclosed |
| US-5721276-A | TREATING DISORDERS OF MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-02-24 | — | — | US | disclosed |
| EP-0745584-A1 | Arylalkyl(thio) carboxamides compounds with affinity for melatonine receptors, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |