Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.56 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.51 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 2/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.48 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10635192 | 0.89 | FFAR1 (0.66) | MAOBFFAR1FFAR4POLBPTGER4 | |
| SCHEMBL10635313 | 0.82 | CYP4F2 (0.53) | MAOBFFAR1FFAR4POLBLMNA | |
| SCHEMBL3880576 | 0.81 | FFAR1 (0.52) | MAOBPARP10FFAR1FFAR4SPHK2 | |
| SCHEMBL2912575 | 0.81 | FFAR1 (0.66) | MAOBPARP10FFAR1FFAR4SPHK2 | |
| SCHEMBL2170636 | 0.81 | FFAR1 (0.77) | PARP10FFAR1FFAR4NR4A2NR4A1 | |
| SCHEMBL10893534 | 0.80 | FFAR1 (0.66) | MAOBFFAR1FFAR4POLBLMNA | |
| SCHEMBL23509390 | 0.80 | MAOB (0.61) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL28970950 | 0.80 | MAOB (0.61) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL6035603 | 0.79 | MAOB (0.64) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL8694064 | 0.79 | PPARD (0.53) | PARP10FFAR1FFAR4SPHK2SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7589126-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-09-15 | — | — | US | disclosed |
| US-7563822-B2 | Agents for the prevention or treatment of renal diseases | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2009-07-21 | — | — | US | disclosed |
| EP-1331221-B1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | KISSEI PHARMACEUTICAL (JP) | 2009-01-14 | — | — | EP | disclosed |
| CN-100439329-C | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing them and intermediates for their preparation | KISSEI PHARMACEUTICAL (JP) | 2008-12-03 | — | — | CN | disclosed |
| CN-100341496-C | Agent for preventing or treating kidney disease | KISSEI PHARMACEUTICAL (JP) | 2007-10-10 | — | — | CN | disclosed |
| US-7256215-B2 | Crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-08-14 | — | — | US | disclosed |
| US-7217832-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-05-15 | — | — | US | disclosed |
| US-20070105829-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co.,Ltd. | 2007-05-10 | — | — | US | disclosed |
| US-7208524-B2 | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2007-04-24 | — | — | US | disclosed |
| US-20060205812-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. | 2006-09-14 | — | — | US | disclosed |
| US-20060116361-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2006-06-01 | — | — | US | disclosed |
| CN-1652761-A | Agent for preventing or treating kidney disease | KISSEI PHARMACEUTICAL (JP) | 2005-08-10 | — | — | CN | disclosed |
| US-20050143457-A1 | Novel crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-06-30 | — | — | US | disclosed |
| US-20050107354-A1 | active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative or a pharmaceutical acceptable salt thereof; excellent inhibitory effect on mesangial cell proliferation and decreasing effect on urine protein excretion | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2005-05-19 | — | — | US | disclosed |
| EP-1486485-A1 | NOVEL CRYSTALS OF 5-HYDROXYCARBAMIMIDOYL-2-HYDROXYBENZENESULFONAMIDE DERIVATIVE | Kissei Pharmaceutical Co., Ltd. (JP) | 2004-12-15 | — | — | EP | disclosed |
| CN-1468215-A | 5-amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | ����ҩƷ��ҵ��ʽ���� | 2004-01-14 | — | — | CN | disclosed |
| EP-1331221-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | Kissei Pharmaceutical Co., Ltd. (JP) | 2003-07-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143457-A1 | Novel crystals of 5-hydroxycarbamimidoyl-2-hydroxybenzenesulfonamide derivative | HABP2, F13B, F5 | MAOB 1265/4885PARP10 3988/4885FFAR1 2376/4885 |
| US-20050107354-A1 | active ingredient a 5-amidino-2-hydroxybenzenesulfonamide derivative or a pharmaceutical acceptable salt thereof; excellent inhibitory effect on mesangial cell proliferation and decreasing effect on urine protein excretion | REN, GLS, GRB2 | MAOB 3398/4885PARP10 4356/4885FFAR1 2921/4885 |
| US-20060205812-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | F12, F2, F5 | MAOB 143/4885PARP10 3150/4885FFAR1 2141/4885 |
| US-20060116361-A1 | 5-Amidino-2-hydroxybenzenesulfonamide derivatives, pharmaceutical compositions containing the same and intermediates for their preparation | F12, F2, F5 | MAOB 143/4885PARP10 3150/4885FFAR1 2141/4885 |
| US-20070105829-A1 | 5-AMIDINO-2-HYDROXYBENZENESULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND INTERMEDIATES FOR THEIR PREPARATION | F12, F2, F5 | MAOB 143/4885PARP10 3150/4885FFAR1 2141/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.