Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 3/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GRK2 | P25098 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6608669 | 0.90 | KMT2A (0.48) | RAB9APTGESMAPTPOLBGRK2 | |
| SCHEMBL7390326 | 0.88 | PTGES (0.43) | PTGESDAGLAKCNH2MAPTLMNA | |
| SCHEMBL8029945 | 0.84 | MAPT (0.45) | PTGESKCNH2MAPTLMNAHPGD | |
| SCHEMBL6610937 | 0.82 | POLB (0.48) | PTGESMAPTLMNAPOLBGRK2 | |
| SCHEMBL6614500 | 0.82 | KMT2A (0.52) | NPC1RAB9AMAPTLMNAHPGD | |
| SCHEMBL5656058 | 0.79 | POLB (0.48) | PTGESMAPTPOLBGRK2PPARG | |
| SCHEMBL6611061 | 0.79 | MAPT (0.43) | NPC1RAB9AMAPTLMNAPOLB | |
| SCHEMBL6610598 | 0.78 | FLT1 (0.52) | KCNH2MAPTLMNAHPGDTP53 | |
| SCHEMBL6609835 | 0.78 | POLB (0.48) | PTGESMAPTLMNAPOLBGRK2 | |
| SCHEMBL6610841 | 0.78 | KEAP1 (0.48) | PTGESHPGDL3MBTL1POLBGRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071903-A | ENZYME INHIBITORS OF MATRIX METALLOPROTEINASES (MMPS); ANTITUMOR,-CARCINOGENIC AND -ARTHRITIC AGENTS; OSTEOARTHRITIS; RHEUMATOID DISEASES; DEGENERATIVE CARTILAGE LOSS; LONG-ACTING, ORALLY BIOAVAILABLE NONPEPTIDE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 2000-06-06 | — | — | US | disclosed |