Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | APAF1 | O14727 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070540 | 0.84 | KMT2A (0.61) | KMT2AMAPTAPAF1ALDH1A1GAA | |
| SCHEMBL6779279 | 0.84 | TDP1 (0.54) | KMT2AALDH1A1MEN1HPGDHDAC8 | |
| SCHEMBL6778346 | 0.84 | TDP1 (0.54) | KMT2AALDH1A1MEN1HPGDHDAC8 | |
| SCHEMBL20707259 | 0.82 | HDAC1 (0.53) | KMT2AMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL6774135 | 0.82 | HDAC1 (0.53) | KMT2AMAPTALDH1A1RAB9AMEN1 | |
| SCHEMBL11283988 | 0.81 | KMT2A (0.64) | KMT2AMAPTAPAF1ALDH1A1GAA | |
| SCHEMBL8375889 | 0.81 | KMT2A (0.44) | KMT2AMAPTAPAF1ALDH1A1GAA | |
| SCHEMBL11852813 | 0.79 | KMT2A (0.61) | KMT2AMAPTAPAF1ALDH1A1GAA | |
| SCHEMBL11280189 | 0.78 | KMT2A (0.68) | KMT2AMAPTAPAF1ALDH1A1GAA | |
| SCHEMBL751414 | 0.78 | ALDH1A1 (0.54) | MAPTALDH1A1RAB9AHDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133274-A | TREATING DISEASE MEDIATED BY INTRACELLULAR SIGNALING THROUGH ONE OR TWO SPECIFIC INTRACELLULAR SIGNALING PATHWAYS; A XANTHINYL HAVING AT LEAST ONE NITROGEN SUBSTITUTED BY AN HYDROXYALKYL; ANTITUMOR,-CARCINOGENIC,-ARTHRITIC AGENTS | CELL THERAPEUTICS, INC. (US) | 2000-10-17 | — | — | US | disclosed |