Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CRHBP | P24387 | 2/20 | 0.61 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8019523 | 0.91 | HTR6 (0.70) | THRBHTR6POLBALDH1A1HPGD | |
| SCHEMBL8029242 | 0.89 | CRHBP (0.74) | THRBHTR6POLBALDH1A1HPGD | |
| SCHEMBL8027278 | 0.85 | HTR6 (0.85) | THRBHTR6POLBMAPTRXFP1 | |
| SCHEMBL8029081 | 0.80 | HPGD (0.84) | THRBHTR6POLBALDH1A1HPGD | |
| SCHEMBL8028196 | 0.80 | HPGD (0.84) | THRBHTR6POLBALDH1A1HPGD | |
| SCHEMBL8019460 | 0.79 | HTR6 (0.60) | THRBHTR6ALDH1A1HPGDMAPT | |
| SCHEMBL8026556 | 0.79 | KDM4E (0.64) | THRBHTR6POLBALDH1A1HPGD | |
| SCHEMBL8019326 | 0.77 | HTR6 (0.98) | THRBHTR6POLBMAPTRXFP1 | |
| SCHEMBL8030163 | 0.75 | HTR6 (1.00) | HTR6POLBMAPTRXFP1 | |
| SCHEMBL8019071 | 0.75 | HTR6 (0.76) | HTR6POLBMAPTLMNARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009093934-A2 | SUBSTITUTED 3-SULPHONYL-[1,2,3]TRIAZOLO [1,5-A]PYRIMIDINES-ANTAGONISTS OF SEROTONIN 5-HT6 RECEPTORS, MEDICINAL SUBSTANCE, PHARMACEUTICAL COMPOSITION, MEDICINAL PREPARATION AND METHODS FOR THE PRODUCTION THEREOF | ALLA CHEM, LLC (US) | 2009-07-30 | — | — | WO | disclosed |