Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6773066 | 0.84 | CTSS (0.44) | KLK5CTSSGPR139RAB9ANPC1 | |
| SCHEMBL8009085 | 0.84 | GPR139 (0.46) | CTSSGPR139RAB9ANPC1MAPT | |
| SCHEMBL6773596 | 0.81 | GPR139 (0.51) | CTSSGPR139RAB9ATP53 | |
| SCHEMBL1673615 | 0.81 | KLK5 (0.56) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL1673614 | 0.81 | KLK5 (0.56) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL12122453 | 0.76 | CTSS (0.64) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL1273042 | 0.76 | CTSS (0.64) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL26818324 | 0.74 | CTSS (0.49) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL23332639 | 0.73 | KLK5 (0.59) | KLK5CTSSACECTSLCTSB | |
| SCHEMBL28582380 | 0.73 | KLK5 (0.59) | KLK5CTSSACECTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |