SCHEMBL8020929

SCHEMBL8020929

CCCN(CC)C(=O)COc1ccccc1N(CC(=O)N(C)c1ccccc1)C(=O)CNC(=O)Nc1cccc(C)c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 2/20 0.37
KMT2A Q03164 6/20 0.37
MEN1 O00255 5/20 0.37
NPSR1 Q6W5P4 2/20 0.37
LMNA P02545 1/20 0.37
THRB P10828 1/20 0.37
PKM P14618 1/20 0.37
MAPK1 P28482 3/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
TP53 P04637 1/20 0.35
CASP1 P29466 1/20 0.35
CASP7 P55210 1/20 0.35
HSD17B10 Q99714 1/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
NTSR1 P30989 1/20 0.35
HTT P42858 1/20 0.35
NOD2 Q9HC29 1/20 0.35
TSHR P16473 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8030598 0.95 KMT2A (0.38) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8030026 0.91 BDKRB2 (0.43) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8033894 0.89 SMN1; SMN2 (0.41) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8030385 0.88 BDKRB2 (0.41) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8020588 0.86 BDKRB2 (0.40) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL9134979 0.84 RAB9A (0.44) BDKRB2KMT2AMEN1LMNASMN1; SMN2
SCHEMBL8020951 0.83 POLB (0.41) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8020593 0.83 MAPK1 (0.45) KMT2AMEN1THRBPKMMAPK1
SCHEMBL8030352 0.83 KMT2A (0.40) BDKRB2KMT2AMEN1NPSR1LMNA
SCHEMBL8030207 0.83 KMT2A (0.44) KMT2AMEN1NPSR1THRBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985660-A1 AMINOPHENOL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed