Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 19/20 | 0.39 |
| ▸ | GUCY1A2 | P33402 | 19/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 19/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 19/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.38 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4000871 | 0.93 | L3MBTL1 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3998970 | 0.91 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL4000642 | 0.83 | GUCY1B2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3995946 | 0.82 | CYP2C9 (0.41) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1S1PR1 | |
| SCHEMBL4004104 | 0.82 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL4003135 | 0.82 | PTGDR2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PRKD3 | |
| SCHEMBL3997108 | 0.80 | ITGB2 (0.45) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1S1PR1 | |
| SCHEMBL3997847 | 0.80 | CETP (0.42) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1PRKD3 | |
| SCHEMBL3229753 | 0.79 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3998943 | 0.78 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |