Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1B2 | O75343 | 20/20 | 0.45 |
| ▸ | GUCY1A2 | P33402 | 20/20 | 0.45 |
| ▸ | GUCY1A1 | Q02108 | 20/20 | 0.45 |
| ▸ | GUCY1B1 | Q02153 | 20/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998970 | 0.92 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL4000871 | 0.91 | L3MBTL1 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7937211 | 0.89 | GUCY1B2 (0.43) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3234865 | 0.88 | GUCY1B2 (0.44) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL8021025 | 0.83 | GUCY1B2 (0.39) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3229753 | 0.80 | GUCY1B2 (0.47) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3995161 | 0.79 | CCR5 (0.51) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL7934714 | 0.79 | MAPT (0.36) | — | |
| SCHEMBL3994735 | 0.77 | GUCY1A1 (0.52) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3996895 | 0.75 | MAPT (0.48) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071504-A1 | 2,6-DISUBSTITUTED PYRIDINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-06-11 | — | — | WO | disclosed |