Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F9 | P00740 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 8/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.37 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327453 | 0.90 | F9 (0.41) | F9F10EDNRAGPR132MAOA | |
| SCHEMBL8023432 | 0.83 | F9 (0.39) | F9F10GPR132MAOAKDM4E | |
| SCHEMBL8010359 | 0.80 | MMP13 (0.43) | F9F10GPR132MAOAKDM4E | |
| SCHEMBL8023719 | 0.75 | F9 (0.48) | F9F10EDNRAPRKAB2PRKAG1 | |
| SCHEMBL8027223 | 0.72 | EDNRA (0.44) | F9F10EDNRAGPR132CMKLR2 | |
| SCHEMBL8027254 | 0.72 | MMP13 (0.44) | F9F10ACHEMAOBBCHE | |
| SCHEMBL8024530 | 0.70 | F9 (0.48) | F9F10GPR132KDM4EALDH1A1 | |
| SCHEMBL10953368 | 0.69 | F9 (0.51) | F9F10GPR132MAOACYP1A2 | |
| SCHEMBL8021827 | 0.69 | KMT2A (0.45) | EDNRAMAOBALDH1A1HPGD | |
| SCHEMBL8010798 | 0.69 | HPGD (0.53) | F9F10MAOAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6040309-A | ACTIVE MATERIAL TREATING OF RESTENOSIS, RENAL FAILURE, PULMONARY HYPERTENSION, BENIGN PROSTATIC HYPERTROPHY, MALE ERECTILE DYSFUNCTION, CONGESTIVE HEART FAILURE, STROKE, ANGINA, ATHEROSCLEROSIS, CEREBRAL AND CARDIAC ISCHAEMIA | PFIZER, INC. (US) | 2000-03-21 | — | — | US | disclosed |